John Kuriyan

The Kuriyan laboratory is interested in the structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction and DNA replication. We use x-ray crystallography to determine the three-dimensional structures of proteins involved in signaling and replication, as well as biochemical, biophysical, and computational analyses to figure out how they work. Two major focuses in the laboratory are understanding the allosteric mechanisms that enable proteins to be exquisitely sensitive to input signals and processive DNA replication.