Members of the Executive Committee


Fenyong Liu(Chair of the Group)
Bing K. Jap (Chair of the Executive Committee)
George F. Sensabaugh (Head Graduate Advisor)
Mina J. Bissell
Judith Campisi
Jack F. Kirsch
Barry Shane


Members of the Graduate Group
(* Designates non-members of the Berkeley Academic Senate)

Thomas C. Alber (Molecular and Cell Biology)
tom@ucxray.berkeley.edu
Defining the molecular logic of regulatory circuits in physiology and disease, protein-protein interaction.
Link to: further description of his research interests and the Alber Lab.

Bruce N. Ames (Molecular and Cell Biology; LBNL)
bnames@berkeley.edu
Aging and cancer mechanisms; oxidants and antioxidants in aging.
Link to: further description of his research interests.

Nancy K. Amy (Nutritional Sciences & Toxicology)
nkamy@berkeley.edu
Gene functions necessary for utilization of trace metals; regulation of metalloenzyme synthesis.
Link to: further description of her research interests.

Carolyn Bertozzi (Chemistry)
crb@berkeley.edu
The research projects in our lab share the common mission of bringing concepts from synthetic chemistry into biological systems that are in need of new experimental approaches. Glycobiology is a major focus area, with recent projects oriented toward the identification of glycan biomarkers of cancer and molecular imaging of changes in glycosylation associated with development and disease. In parallel, we are seeking new avenues for treating Mycobacterium tuberculosis infection. Our projects in this area focus on pathways of sulfur metabolism and the identification of enzymes and metabolites that are critical for virulence and survival within the host. Finally, we are developing new technologies to probe and manipulate cells using nanomaterials. Projects in this area focus on modification of carbon nanotubes for cell biosensing, and their employment in nanoinjectors.
Link to: the Bertozzi Research Group.

Mina J. Bissell* (LBNL)
mjbissell@lbl.gov
Regulation of tissue-specific gene expression in normal and malignant breast cells with specific emphasis on signal transduction by extracellular matrix (ECM). Relation of cellular structure and function.
Links to: the Bissell Lab.

Steven Brenner (Plant & Microbial Biology)
brenner@compbio.berkeley.edu
Gene regulation by alternative splicing and nonsense-mediated mRNA decay; prediction of protein function using Bayesian phylogenomics; medical and environmental metagenomics, personal genomics; structural genomics and proteins complexes.
Link to: further description of his research interests.

George A. Brooks (Integrative Biology)
gbrooks@berkeley.edu
Biochemistry and energetics of human muscular performance.
Links to: further description of his research interests and his CV.

Bob. B. Buchanan (Plant & Microbial Biology)
view@berkeley.edu
Plant biochemistry, seed germination, cereal technology, bioremediation.
Link to: further description of his research interests.

Judith Campisi* (LBNL)
jcampisi@lbl.gov
Molecular, cellular and evolutionary biology of aging and cancer. Roles of cellular senescence and apoptosis. DNA damage and repair, and telomeres and genomic instability.
Links to: further description of her research interests.

John E. Casida (Environmental Science, Policy, & Management; and Nutritional Sciences & Toxicology)
ectl@berkeley.edu
Mode of action and metabolism of pesticides and other organic toxicants.
Link to: further description of his research interests.

Douglas S. Clark (Chemical Engineering)
clark@berkeley.edu
Biochemical engineering, with emphasis on enzyme technology and stabilization, thermophilic bacteria and high-temperature bioprocesses, and noninvasive methods for studying metabolism.
Link to: Clark Lab.

Benito O. de Lumen (Nutritional Sciences & Toxicology)
nitto@berkeley.edu
Biochemistry and molecular biology of seed development in legumes and cereals (rice) as food sources; molecular biosynthesis of methionine-rich proteins, galactose oligosaccharides and starch in seeds.
Link to: further description of his research interests.

Kenneth H. Downing* (LBNL)
khdowning@lbl.gov
Development and application of electron microscopy in high-resolution structural studies of proteins. Electron crystallographic study of tubulin and associated ligands, and of G-protein coupled receptors.
Link to: Downing Lab.

Peter Duesberg (Molecular and Cell Biology)
duesberg@berkeley.edu
Genetic basis of viral and chemical carcinogenesis, particularly by non-genotoxic carcinogens. Structure and replication of retroviruses and mechanisms of viral pathogenesis and oncogenesis.
Link to: further description of his research interests.

Joe W. Gray* (LBNL)
jwgray@lbl.gov
Cancer systems biology approaches to elucidation of mechanisms by which genomic, transcriptional and proteomic abnormalities occur in selected cancers and how these abnormalities contribute to cancer pathophysiology; development of improved early cancer detection; and optimization of strategies for marker guided cancer therapy.
Link to: Gray Lab.

Lin He (Molecular & Cell Biology)
glinhe@gmail.com
miRNAs are a class of small, non-coding RNAs that regulate post-transcriptional silencing of specific mRNAs. Emerging evidence has suggested these small RNAs as important gene regulators for diverse developmental and pathological processes. Using mouse tumor models and cell culture systems, the He lab aims to characterize the miRNAs functions in the oncogene and tumor suppressor network.
Link to: further description of her research interests.

Bing K. Jap* (LBNL)
bkjap@lbl.gov
Structure biology and functional mechanisms of selected membrane proteins such as water channels, respiratory complexes and g-secretase, and soluble protein complexes such as proteasomes, protein 4.1 with its associeted proteins and DNA-PK.
Link to: Jap Lab.

Jay Keasling (Chemical Engineering)
keasling@berkeley.edu
The research in the Keasling Laboratory focuses on the metabolic engineering of microorganisms for degradation of environmental contaminants or for environmentally friendly synthesis. To that end, we have developed a number of new genetic and mathematical tools to allow more precise and reproducible control of metabolism. These tools are being used in such applications as synthesis of biodegradable polymers, accumulation of phosphate and heavy metals, and degradation of chlorinated and aromatic hydrocarbons, biodesulfurization of fossil fuels, and complete mineralization of organophosphate nerve agents and pesticides.
lLink to: the Keasling lab.

Sung-Hou Kim (Chemistry; LBNL)
shkim@lbl.gov
Structural biology of: (1) molecules involved in cell growth, cell cycle, and signal transduction; (2) proteins and RNA's from hyperthermal organisms.
Link to: Kim Lab.

Jack F. Kirsch (Chemistry, Molecular and Cell Biology; LBNL)
jfkirsch@berkeley.edu
Genetic engineering approaches to enzyme mechanisms, protein design, and antigen/antibody recognition.
Link to: Kirsch Lab
.

Judith P. Klinman (Chemistry)
klinman@berkeley.edu
The overall focus of research concerns fundamental principles in enzyme-catalyzed reactions; the research utilizes broadly based and combines kinetic, spectroscopic, stereochemical and molecular biological techniques.
Link to: Klinman Lab.

Terumi Kohwi-Shigematsu* (LBNL)
tkohwi-Shigematsu@lbl.gov
Study the role of SATB, which predominantly expressed in the T-cell lineage, in regulating the expression of numerous genes and chromatin structure during T-cell development.
Link to: further description of her research interests.

Isao Kubo (Environmental Science, Policy, & Management; and Nutritional Sciences & Toxicology)
ikubo@berkeley.edu
Natural product research with emphasis on structure-activity relationships of enzyme mechanisms.
Link to: further description of his research interests.

John Kuriyan (Molecular & Cell Biology)
kuriyan@berkeley.edu
The Kuriyan laboratory is interested in the structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction and DNA replication. We use x-ray crystallography to determine the three-dimensional structures of proteins involved in signaling and replication, as well as biochemical, biophysical, and computational analyses to figure out how they work. Two major focuses in the laboratory are understanding the allosteric mechanisms that enable proteins to be exquisitely sensitive to input signals and processive DNA replication.
Link to: the Kuriyan lab.

Stuart M. Linn (Molecular and Cell Biology)
slinn@socrates.berkeley.edu
Oxidative DNA damage and repair; mitochondrial DNA damage. Mammalian DNA polymerases.
Link to: further description of his research interests and Linn Lab.

Fenyong Liu (Public Health)
liu_fy@berkeley.edu
Biochemistry of nucleic acids and RNA enzymology (ribozymes). Biology of human herpes viruses and development of nucleic acid-based antiviral therapeutic agents.
Link to: further description of his research interests.

Sangwei Lu (Public Health)
sangwei@berkeley.edu
Pathogenesis and transmission of Salmonella; foodborne pathogens; Foodborne diseases - detection and prevention
Link to: further description of her research interests.

Anastasios Melis (Plant & Microbial Biology)
melis@berkeley.edu
Biochemistry and molecular biology of a damage and repair process in chloroplasts; hydrogen production in green algae by a process of photosynthesis; chloroplast acclimation mechanisms to the prevailing environmental conditions.
Link to: further description of his research interests.

Joseph L.Napoli (Nutritional Sciences & Toxicology)
jna@berkeley.edu
The vitamin A metabolite retinoic acid regulates gene expression from conception through death. This lab studies regulation of retinoic acid biosynthesis during mammalian development and aging.
Link to: further description of his research interests
.

Randy Schekman (Molecular & Cell Biology)
schekman@berkeley.edu
Our lab studies membrane assembly, vesicular transport, and membrane fusion among organelles of the secretory pathway. Basic principles that emerged from our past and on-going studies in yeast are now being applied to studies of genetic diseases of protein transport.
Link to: Schekman lab.

George F. Sensabaugh (Public Health)
sensaba@berkeley.edu
Genetic variation in humans at the protein and DNA levels; forensic biology; microbial population genetics.
Link to: further description of his research interests.

Barry Shane (Nutritional Sciences & Toxicology)
bandie@berkeley.edu
Nutritional biochemistry; regulation of genes and enzymes involved in one carbon and vitamin metabolism. Genetic heterogeneity and nutrient requirements.
Link to: further description of his research interests.

Martyn Smith (Public Health)
martynts@berkeley.edu
Toxicology; mechanisms of cellular and genetic damage; biological markers.
Link to: further description of his research interests.

Andreas Stahl (Nutritional Sciences & Toxicology)
astahl@berkeley.edu
Our major focus is to elucidate the molecular mechanisms of energy homeostasis and obesity-associated disorders. Specifically, current research focuses on the role of fatty acids in the development of diabetes, cancer, cardio-vascular disease and hepatobiliary diseases. Using biochemical, genetic, and state-of-the-art imaging technologies we have discovered a novel family of proteins that regulate fatty acid fluxes and demonstrated that inhibiting specific members of this group can significantly improve body weight, insulin sensitivity, and liver health and thus may lead to the development of novel treatment strategies for obesity-related diseases.
Link to: lab homepage.

Hei Sook Sul (Nutritional Sciences & Toxicology)
hsul@berkeley.edu
Transcriptional regulation of lipogenesis and the role of USF and SREBP in the activation of fatty acid synthase promoter. Regulation of adipocyte differentiation, Pref-1 and ADSF/resistin, factors which are secreted from adipose tissue and inhibit adipogenesis. 3T3-L1 cells in culture and transgenic/ knockout mice are used to elucidate molecular mechanisms underlying these processes which contribute to obesity.
Link to: further description of her research interests.

Christopher Vulpe (Nutritional Sciences & Toxicology)
vulpe@berkeley.edu
Genetic/Genomic approaches to the identification of genes involved in copper and iron metabolism and characterization of the corresponding proteins is the primary focus of my laboratory.
Link to: further description of his research interests.

Qing Zhong (Molecular & Cell Biology)
qingzhong@berkeley.edu
Apoptosis and autophagy are critical in tissue homeostasis, genome maintenance and quality control of cellular organelles. We are interested in DNA damage induced apoptosis and stress induced autophagy, two pathways involved in pathogenesis of human cancers, neurodegenerative disease, heart disease, infectious disease, and diabetes.
Link to further description of his research interests.

(* Designates non-members of the Berkeley Academic Senate)

 

 

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